INVITATION
Dear Colleagues,
Turkish and British Associations for the Study of Liver (TASL-BASL) are pleased to announce a digital monothematic conference, “Drug-induced Liver Injury: Unresolved questions and unmet needs” on March 12-13, 2021. We hope that the programme will be a timely and welcome opportunity to reflect upon an area of critical importance for clinicians, researchers, scientists, pharma and other health care professionals.
Drugs and herbs are a common aetiology underlying acute liver injury. The number, variety and mechanism of action of drugs in use continues to expand. Along with this, interest and importance of drug-induced liver injury (DILI) has grown. Dissemination of knowledge related to DILI and a shared understanding is crucial to improve its diagnosis and safety of medications.
On behalf of TASL and BASL, we welcome you to join experts from Turkey and the United Kingdom in this event where we aim to appraise recent advances and emerging context in the field to identify priorities for future collaboration. We are excited to have this opportunity to create a partnership between TASL and BASL as well as to share the cutting-edge information with regards to DILI.
We look forward to seeing you all,
Prof. Guruprasad Aithal
President, BASL
Prof. Ramazan Idilman
President, TASL
BASL Organizer
Guruprasad Aithal
TASL Organizer
Fulya Gunsar
Scientific Secretariat
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Cemal Nuri Erçin
Mujdat Zeybel
Gupse Adalı
MAIN TOPICS
Session 1: Hepatotoxicity: Epidemiology and pathogenesis
- Epidemiology – Pro- Euro- DILI network registry
- TASL-Hepatotoxicity Database
- Host and drug dependant risk factors for hepatotoxicity
- Mechanisms of injury and immune-mediated reactions
- Pharmacogenomics and DILI
Session 2: Clinical manifestations
- Clinical presentation and patterns of DILI
- Oral presentation
- Drug-induced autoimmune hepatitis
- Herbal and supplement-induced liver injury (HILI/SILI)
Session 3: The other presentations of hepatotoxicity
- Acute fatty liver and drug-associated fatty liver disease(with case)
- Liver toxicity due to treatments for COVİD(with case)
- Check point inhibitor induced liver injury (CHILI)
Session 4: Toxic hepatitis and drug-drug interaction during chronic viral hepatitis
- Toxic hepatitis and drug-drug interaction during HBV treatment
- Toxic hepatitis and drug-drug interaction during HCV treatment in the era of DAA
Session 5: Causality assessment and diagnosis of DILI
- Laboratory workup and imaging, Liver biopsy: when and whom?
- Causality assessment methods and diagnosis
- Liver histopathology
Session 6: Oral presentations of Selected Posters
Session 7: Severity and Prognosis of DILI
- What is coming as new biomarkers for DILI?
- Severity assessment and natural history chronic DILI
- Re-challenge, recurrent DILI (with case)
- Oral presentation
Session 8: Management in severe cases
- General measures and specific therapies
- Difficult decisions in management of severe DILI
- Controversies in severe DILI: From EASL guideline to clinical practice
Session 9: Drug-induced acute liver failure
- Mushroom poisoning and acute liver failure (with case)
- Management of drug-induced ALF
- Living donor liver transplant in drug-induced ALF
- Future for DILI: Unresolved questions and unmet needs
SCIENTIFIC PROGRAM
| 12th of March 2021 Friday | ||
| 13:15 - 13:30 | Opening Guruprasad Aithal, Ramazan Idilman, Fulya Günşar |
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| Session - 1: Hepatotoxicity: Epidemiology and Pathogenesis Chairs: Ramazan Idilman, Marsha Morgan |
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| Epidemiology – Pro- Euro- DILI network registry Jane Grove |
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| TASL-Hepatotoxicity Database Mujdat Zeybel |
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| Host and drug dependant risk factors for hepatotoxicity Cemal Nuri Ercin |
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| Mechanisms of injury and immune-mediated reactions Ye Htun Oo |
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| Pharmacogenomics and DILI Guruprasad Aithal |
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| Discussion | ||
| 15:30 - 15:40 | BREAK | |
| Session - 2: Clinical manifestations Chairs: Guruprasad Aithal, Cihan Yurdaydin |
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| Clinical presentation and patterns of DILI William Griffiths |
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| Oral presentation ( Case1: Ilker Turan - Case 2: Edmond Atalla: Dilemmas in DILI | ||
| Drug-induced autoimmune hepatitis Fulya Gunsar |
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| Herbal and supplement-induced liver injury (HILI/SILI) Marsha Morgan |
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| Discussion | ||
| 17:20 - 17:30 | BREAK | |
| Session - 3: The other presentations of hepatotoxicity Chairs: Halis Şimşek , Mesut Akarsu |
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| Acute fatty liver and drug-associated fatty liver disease(with case) Yusuf Yilmaz |
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| Liver toxicity due to treatments for COVİD (with case) Yasemin Balaban |
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| Check point inhibitor induced liver injury (CHILI) Arjuna Singanayagam |
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| Discussion | ||
| 13th of March 2021 Saturday | ||
| Session - 4: Toxic hepatitis and drug reactions during chronic viral hepatitis Chairs: Stephen Ryder, Sabahattin Kaymakoğlu |
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| İmmunosupressive drugs induced HBV flares Gupse Adalı |
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| Liver Toxicity and drug-drug interaction during HCV treatment in the era of DAA: Stephen Ryder |
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| Discussion | ||
| Session - 5: Causality assessment and diagnosis of DILI Chairs: Ye Htun Oo, Murat Harputluoğlu |
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| Laboratory workup and imaging, Liver biopsy: when and whom? (with case) Bülent Degertekin |
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| Causality assessment methods and diagnosis Marsha Morgan |
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| Liver histopathology Philip Kaye |
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| Discussion | ||
| BREAK | ||
| Session - 6 | ||
| Oral presentations of Selected Posters Chairs: Tamir Rashid, Meral Akdoğan Kayhan |
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 Satellite SymposiumVEMLIDY—For the Flow of Life with Chronic Hepatitis B Monitoring Chronic Hep B patients during the pandemic to prevent drug toxicities Chair: Prof. Dr. Sabahattin Kaymakoğlu Speaker: Prof. Dr. Yusuf Yilmaz |
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| Session - 7: Severity and Prognosis of DILI Chairs: John Dillon, Ulus Akarca |
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| What is coming as new biomarkers for DILI? James Dear |
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| Severity assessment and natural history chronic DILI Murat Kıyıcı |
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| Re-challenge, recurrent DILI Nurdan Tözün |
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| Oral presentation (Case 1 during Covid teratment) Fatih Güzelbulut |
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| Discussion | ||
| 16:10 - 16:20 | BREAK | |
| Session - 8: Management in severe cases Chairs: Osman Ozdogan, Mehmet Demir |
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| General measures and specific therapies Suna Yapalı |
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| Difficult decisions in management of severe DILI (with case) Hale Gokcan |
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| Discussion | ||
| Session - 9: Drug-induced acute liver failure Chairs: Zeki Karasu , Rebecca Jones |
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| Mushroom poisoning and acute liver failure (with case) Gökhan Kabacam |
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| Management of drug-induced ALF Adrian Reuben |
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| Living donor liver transplant in drug-induced ALF : Turkish Chapter Murat Akyıldız |
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| Future for DILI: Unresolved questions and unmet needs Guruprasad Aithal |
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| Discussion | ||
| Closing remarks Fulya Günşar, Guruprasad Aithal |
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ABSTRACT
ABSTRACTS
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